Inducible deletion of JunB and Jun and in the epidermis of adult mice. Mice carrying floxed alleles for the Jun and/or JunB locus were used to delete one or both genes in the epidermis by inducible Cre-recombinase activity. (a) Schematic representation of the floxed Jun and JunB loci before and after tamoxifen-induced activation of the Cre-ER-fusion protein, which is under the control of the keratin 5 promoter. (b) Eight-week-old mice were injected for five consecutive days with tamoxifen to activate Cre-mediated deletion of Jun and JunB. Two weeks after the last injection ((c), (e) and (g), control mice), the double-mutant mice ((d), (f) and (h)) showed a strong skin and arthritis phenotype reminiscent of psoriasis mainly affecting the (d) ears, (f) tail and (h) paws. H&E staining of (e) control mice and (f) mutant skin mice reflects the histological hallmarks of psoriasis with abnormally thickened epidermis, parakeratosis, hyperkeratosis and fingerlike epidermal projections into the dermis.
Zenz et al. Arthritis Research & Therapy 2008 10:201 doi:10.1186/ar2338