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Factors that may mediate the relationship between physical activity and the risk for developing knee osteoarthritis

Donna M Urquhart1*, Cathy Soufan1, Andrew J Teichtahl1, Anita E Wluka12, Fahad Hanna1 and Flavia M Cicuttini1

Author Affiliations

1 Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Commercial Road, Melbourne 3004, Australia

2 Baker Heart Research Institute, AMREP Centre, Commercial Road, Melbourne, 3004, Australia

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Arthritis Research & Therapy 2008, 10:203  doi:10.1186/ar2343

Published: 4 February 2008


Studies investigating the effect of physical activity on risk for developing osteoarthritis at weight-bearing joints have reported conflicting results. We examine evidence to suggest that this may be due to the existence of subgroups of individuals who differ in their response to physical activity, as well as methodological issues associated with the assessment of knee joint structure and physical activity. Recommendations for future studies of physical activity and the development of knee osteoarthritis are discussed.