HMGB1 but not TNF release was reduced by oxaliplatin treatment. RAW 264.7 macrophage-like cells were activated with IFN-γ and LPS in HMGB1-specific or TNF-specific (24 h and 7 h respectively) Elispot plates in the absence or presence of oxaliplatin (ranging from 0.03–0.5 μM) (a). Oxaliplatin inhibited HMGB1 release in a dose-dependent manner. The release of TNF was in contrast not affected (b).
Östberg et al. Arthritis Research & Therapy 2008 10:R1 doi:10.1186/ar2347