Clinical scores from murine collagen-induced arthritis study 1. Animals were given initial injection of type II collagen on day -21 and disease was induced with a second injection on day 0. On day 3 (arrow), pumps were implanted and clinical signs measured twice a week from day 10 to day 28. By day 10, a statistically significant, dose-dependent decrease in the clinical score was observed with all doses of CP-690550 and these remained significant throughout the remainder of the study.
Milici et al. Arthritis Research & Therapy 2008 10:R14 doi:10.1186/ar2365