Histological evaluation of damage to murine knees. Histological sections of knee samples from murine collagen-induced arthritis study 1 were graded as described in Table 1. CP-690550 produced a dose-dependent inhibition of knee damage that reached statistical significance (p < 0.0001) at the 15 mg/kg/day dose relative to vehicle.
Milici et al. Arthritis Research & Therapy 2008 10:R14 doi:10.1186/ar2365