Figure 1.

Effect of spironolactone on the development of nephrotic range proteinuria. The age at onset of nephrotic range proteinuria was compared between treatment groups. At the 36-week time point, 70.8% of the control mice had nephrotic proteinuria (as opposed to 51.3% and 48.6% of the mice treated with 25 mg/kg per day and 50 mg/kg per day, respectively). Sixteen animals were included in each group at the start of the study. P = 0.331, control versus spironolactone 50 mg/kg per day.

Monrad et al. Arthritis Research & Therapy 2008 10:R5   doi:10.1186/ar2353
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