Effect of rosiglitazone and pioglitazone treatment on dual-energy X-ray absorptiometry changes during adjuvant-induced arthritis. Animals were treated daily for 21 days with rosiglitazone (ROSI) 10 mg/kg (n = 8) or pioglitazone (PIO) 30 mg/kg (n = 8) by oral administration. Arthritic (adjuvant-induced arthritis (AIA)) (n = 7) and normal controls (n = 7) were given 0.5% carboxymethylcellulose alone. Dual-energy X-ray absorptiometry analysis was performed in vivo the day before arthritis induction (day 0) and before necropsy (day 21). (a) Changes in whole-body bone mineral content (BMC); (b) changes in fat mass percentage. Data are expressed as means ± SEM. *, P < 0.05 compared with normal controls; #, P < 0.05 compared with AIA controls (ANOVA and Fisher's PLSD post-hoc test). Dn, day n.
Koufany et al. Arthritis Research & Therapy 2008 10:R6 doi:10.1186/ar2354