Role of interleukin-7 in degenerative and inflammatory joint diseases
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Heidelberglaan, 3584 CX Utrecht, The Netherlands
Arthritis Research & Therapy 2008, 10:107 doi:10.1186/ar2395
See related research by Long et al., http://arthritis-research.com/content/10/1/R23Published: 18 April 2008
IL-7 is known foremost for its immunostimulatory capacities, including potent T cell-dependent catabolic effects on bone. In joint diseases like rheumatoid arthritis and osteoarthritis, IL-7, via immune activation, can induce joint destruction. Now it has been demonstrated that increased IL-7 levels are produced by human articular chondrocytes of older individuals and osteoarthritis patients. IL-7 stimulates production of proteases by IL-7 receptor-expressing chondrocytes and enhances cartilage matrix degradation. This indicates that IL-7, indirectly via immune activation, but also by a direct action on cartilage, contributes to joint destruction in rheumatic diseases.