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Highly Accessed Open Badges Editorial

Mechanisms of oral tolerance revisited

Jun Wang and Rene EM Toes*

Author Affiliations

Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands

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Arthritis Research & Therapy 2008, 10:108  doi:10.1186/ar2402

See related research by Park et al.,

Published: 25 April 2008


Oral tolerance induction is thought to depend on special antigen presenting cells in the gut. A new report in the previous issue of Arthritis Research & Therapy supports this idea by demonstrating that indoleamine 2,3-dioxygenase-expressing dendritic cells in Peyer's patches from orally tolerized mice suppress T-cell responses via the generation of CD4+CD25+ regulatory T cells. This finding provides novel input into the mechanisms of oral tolerance that could further facilitate its use for the treatment of autoimmunity and chronic inflammatory reactions.