Table 1

Genetic factors confirmed for or suggestive of association with anticitrulline-peptide antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis


ACPA-positive rheumatoid arthritis

ACPA-negative rheumatoid arthritis


Human leucocyte antigen shared epitope alleles

Human leucocyte antigen DR3

Protein tyrosine phosphatase nonreceptor 22 (PTPN22)

Complement component 5-TNF receptor-associated factor 1 (C5-TRAF1)

TNF╬▒-induced protein 3-oligodendrocyte lineage transcription factor 3 (TNFAIP3-OLIG3)


Cytotoxic T lymphocyte antigen 4 (CTLA4)

Interferon regulatory factor 5 (IRF5)

Signal transducer and activator of transcription 4 (STAT4)

van der Helm-van Mil and Huizinga Arthritis Research & Therapy 2008 10:205   doi:10.1186/ar2384