TNF injection decreases stromal cell-derived factor 1 expression by bone marrow stromal cells. Expression of stromal cell-derived factor 1 (SDF-1) protein by bone marrow cells was examined by immunostaining with anti-SDF-1 antibody. Left panels: pictures taken at power 2 to show the overall view of bone architecture. Right panels: pictures are the insert taken at power 20 to show SDF-1-positive bone marrow osteoblasts (upper panel arrows) in mice receiving PBS injection and to show SDF-1-negative cells (lower panel arrows) in TNF-injected mice. Photographs are representatives of one pair of TNF-injected or PBS-injected mice from three pairs of animals.
Zhang et al. Arthritis Research & Therapy 2008 10:R37 doi:10.1186/ar2391