Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis
Divisions of Rheumatology and Cardiology, David Geffen School of Medicine at University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
Arthritis Research & Therapy 2008, 10:213 doi:10.1186/ar2471
See related editorial by Von Feldt, http://arthritis-research.com/content/10/5/121Published: 29 August 2008
In this review, the authors discuss the formation and structure of high-density lipoproteins (HDLs) and how those particles are altered in inflammatory or stress states to lose their capacity for reverse cholesterol transport and for antioxidant activity. In addition, abnormal HDLs can become proinflammatory (piHDLs) and actually contribute to oxidative damage. The assay by which piHDLs are identified involves studying the ability of test HDLs to prevent oxidation of low-density lipoproteins. Finally, the authors discuss the potential role of piHDLs (found in some 45% of patients with systemic lupus erythematosus and 20% of patients with rheumatoid arthritis) in the accelerated atherosclerosis associated with some chronic rheumatic diseases.