|
Genotype frequencies and RA susceptibility |
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| Gene |
SNP |
Genotypes |
RA (n [%]) |
Controls (n [%]) |
OR (95% CI) |
P value |
|
|
||||||
| IL-13 |
rs1800925 |
TT |
26 (2.9) |
26 (2.8) |
1.0 (0.6–1.9) |
0.9 |
| CT |
271 (29.9) |
276 (29.6) |
1.0 (0.8–1.3) |
0.9 |
||
| CC |
608 (67.2) |
631 (67.6) |
1.0 |
|||
| rs1295686 |
TT |
26 (3.0) |
31 (3.3) |
0.9 (0.5–1.6) |
0.7 |
|
| CT |
251 (29.3) |
283 (30.4) |
0.9 (0.8–1.2) |
0.6 |
||
| CC |
580 (67.7) |
617 (66.3) |
1.0 |
|||
| IL-4 |
rs2227284 |
AA |
56 (6.1) |
47 (4.9) |
1.2 (0.8–1.9) |
0.3 |
| AC |
316 (34.6) |
349 (36.7) |
0.9 (0.8–1.1) |
0.4 |
||
| CC |
541 (59.3) |
554 (58.3) |
1.0 |
|||
| rs2243263 |
CC |
8 (0.9) |
6 (0.6) |
1.4 (0.4–4.8) |
0.6a |
|
| GC |
146 (16.4) |
166 (17.9) |
0.9 (0.7–1.2) |
0.4 |
||
| GG |
738 (82.7) |
753 (81.4) |
1.0 |
|||
| rs2243267 |
CC |
18 (2.0) |
17 (1.8) |
1.1 (0.5–2.3) |
0.8a |
|
| CG |
218 (24.0) |
205 (22.2) |
1.1 (0.9–1.4) |
0.4 |
||
| GG |
672 (74.0) |
702 (76.0) |
1.0 |
|||
| IL-4R |
rs1805010 |
GG |
198 (21.8) |
200 (21.3) |
1.2 (0.9–1.5) |
0.2 |
| AG |
460 (50.7) |
438 (46.6) |
1.3 (1.0–1.6) |
0.03 |
||
| AA |
250 (27.5) |
301 (32.1) |
1.0 |
|||
| rs1801275 |
AA |
38 (4.2) |
41 (4.3) |
1.0 (0.6–1.6) |
1.0 |
|
| AG |
316 (34.6) |
302 (32.0) |
1.1 (0.9–1.4) |
0.2 |
||
| GG |
558 (61.2) |
601 (63.7) |
1.0 |
|||
|
aFisher's exact test. CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis. | ||||||
Marinou et al. Arthritis Research & Therapy 2008 10:R80 doi:10.1186/ar2454 |
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