|
Genotype frequencies of the genes involved in the IL-4/IL-13 pathway and modified Larsen score |
|||||
| Gene |
SNP |
Genotypes |
Patients (n) |
Median LSa |
P |
|
|
|||||
| IL-13 |
rs1800925 |
TT |
26 |
31.0 |
|
| CT |
271 |
27.0 |
0.8 |
||
| CC |
608 |
28.0 |
|||
| rs1295686 |
TT |
26 |
33.5 |
||
| CT |
251 |
25.0 |
0.8 |
||
| CC |
580 |
28.0 |
|||
| IL-4 |
rs2227284 |
AA |
56 |
27.0 |
|
| AC |
316 |
29.0 |
0.6b |
||
| CC |
541 |
29.0 |
|||
| rs2243263 |
CC |
8 |
41.5 |
||
| AC |
146 |
26.0 |
0.3 |
||
| AA |
738 |
28.0 |
|||
| rs2243267 |
CC |
18 |
23.5 |
||
| CG |
218 |
29.0 |
0.9 |
||
| GG |
672 |
28.0 |
|||
| IL-4R |
rs1805010 |
GG |
198 |
24.5 |
|
| AG |
460 |
30.0 |
0.5 |
||
| AA |
250 |
29.0 |
|||
| rs1801275 |
AA |
38 |
28.0 |
||
| AG |
316 |
27.5 |
0.5 |
||
| GG |
558 |
29.0 |
|||
|
aMaximum possible modified (Larsen score) is 160. bBy Cuzick's test for trend. SNP, single nucleotide polymorphism. | |||||
Marinou et al. Arthritis Research & Therapy 2008 10:R80 doi:10.1186/ar2454 |
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