Table 5

Genotype frequencies of IL-4/IL-13 variants and production of autoantibodies
Gene
 SNP
 Genotypes
 Anti-CCP statusa
 RF statusa






Positive (n)
 Negative (n)
 OR (95% CI)
 P
 Positive (n)
 Negative (n)
 OR (95% CI)
 P
IL-13
 rs1800925
 TT
 17
 8
 0.6 (0.3–1.8)
 0.3b
 16
 7
 1.0 (0.4–3.0)
 1.0b


CT
 207
 59
 1.1 (0.7–1.5)
 0.8
 170
 82
 0.9 (0.7–1.3)
 0.6


CC
 458
 138
 1.0
387
 171
 1.0

rs1295686
 TT
 20
 6
 1.0 (0.4–3.0)
 1.0b
 16
 10
 0.7 (0.3–1.8)
 0.5b


CT
 192
 54
 1.0 (0.7–1.5)
 0.8
 161
 72
 1.0 (0.7–1.4)
 1.0


CC
 439
 128
 1.0
367
 165
 1.0
IL-4
 rs2227284
 AA
 42
 14
 0.8 (0.4–1.7)
 0.5
 33
 21
 0.7 (0.4–14)
 0.3


AC
 232
 74
 0.8 (0.6–1.2)
 0.3
 202
 89
 1.0 (0.8–1.5)
 0.8


CC
 419
 113
 1.0
338
 156
 1.0

rs2243263
 CC
 5
 3
 0.5 (0.09–3.1)
 0.4b
 5
 3
 0.8 (0.1–5.0)
 0.7b


AC
 102
 38
 0.8 (0.5–1.2)
 0.2
 89
 44
 0.9 (0.6–1.4)
 0.2


AA
 568
 160
 1.0
465
 213
 1.0

rs2243267
 CC
 17
 1
 5.2 (0.8–218.9)
 0.09b
 13
 4
 1.5 (0.4–6.2)
 0.6b


CG
 167
 48
 1.1 (0.7–1.6)
 0.9
 142
 64
 1.0 (0.7–1.4)
 1.0


GG
 503
 154
 1.0
422
 190
 1.0
IL-4R
 rs1805010
 GG
 150
 43
 0.8 (0.5–1.4)
 0.4
 122
 59
 0.8 (0.5–1.3)
 0.3


AG
 341
 109
 0.8 (0.5–1.2)
 0.2
 288
 136
 0.8 (0.6–1.2)
 0.3


AA
 196
 50
 1.0
165
 64
 1.0

rs1801275
 AA
 31
 5
 2.0 (0.7–6.6)
 0.2
 26
 9
 1.4 (0.6–3.4)
 0.6


AG
 241
 71
 1.1 (0.8–1.5)
 0.7
 197
 92
 1.0 (0.7–1.4)
 1.0


GG
 416
 131
 1.0
351
 165
 1.0

aThe presence of anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) was compared for each single nucleotide polymorphism (SNP) with reference to the commonest genotype. bBy Fisher's exact test for association. CI, confidence interval; OR, odds ratio.

Marinou et al. Arthritis Research & Therapy 2008 10:R80   doi:10.1186/ar2454