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Open Badges Editorial

Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine

Angelo L Gaffo1 and Kenneth G Saag2*

Author Affiliations

1 Birmingham VA Medical Center, 700 19th Street South, Birmingham, AL 35233, USA

2 Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, FOT 820, 1530 3rd Avenue South, Birmingham, AL 35294, USA

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Arthritis Research & Therapy 2008, 10:120  doi:10.1186/ar2524

See related research by Hak and Choi,

Published: 17 October 2008


The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the Third National Health and Nutritional Examination Survey. Menopause increased serum urate and hormone replacement therapy significantly decreased serum urate, although the overall level of change was small. The implications of these urate changes on gout and cardiovascular disease outcomes require further study.