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Virally associated arthritis 2008: clinical, epidemiologic, and pathophysiologic considerations

Dimitrios Vassilopoulos1 and Leonard H Calabrese2*

Author Affiliations

1 Athens University School of Medicine, 2nd Department of Medicine, Hippokration General Hospital, 114 Vass., Sophias Avenue, 115 27 Athens, Greece

2 Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, Department of Rheumatic and Immunologic Diseases, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A50, Cleveland, OH 44195, USA

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Arthritis Research & Therapy 2008, 10:215  doi:10.1186/ar2480

Published: 18 September 2008


Several viruses have been associated with the development of inflammatory arthritis, including the hepatitis viruses (hepatitis B virus and hepatitis C virus), HIV, the parvovirus B19, the human T-cell lymphotropic virus-I, and the alphaviruses. Here, we review the epidemiology, the pathophysiological mechanisms, the pertinent clinical and laboratory findings as well as the principles of therapy of the most common virus-associated arthritides. We believe that the knowledge of these key diagnostic and therapeutic features of virus-associated arthritides is important for the rheumatologist of the 21st century.