Meniscotibial transection (MTX) and partial meniscoectomy (PMX) surgeries lead to degenerative joint disease in mouse knees. Histological sections were collected at the indicated time points and stained with safranin O. Note in both the six-week and 10-week PMX and 10-week MTX surgery groups the loss of proteoglycan staining (arrowhead) in the superficial layers and in the 10-week PMX there is delamination of the superficial layer (arrow). WT, wild-type.
Welch et al. Arthritis Research & Therapy 2009 11:R14 doi:10.1186/ar2604