Analysis of Col1a1, Col10a1 and Sox9 expression in knee cartilage from meniscotibial transection (MTX), partial meniscoectomy (PMX) and sham surgeries. Genes analysed are shown on the left and significance was determined by analysis of variance (ANOVA) with Tukey's post-hoc tests for multiple comparisons. In comparison to Sox9 and Col10a1, Col1a1 is significantly increased at multiple time points in the different surgeries. Gene expression was normalised to an 18S internal control and the normalised expression (arbitrary units) for each gene is shown for the contralateral unoperated right knee, a sham control (left) knee (n = 5) and the operated left knee. Significance to the contralateral and sham controls is indicated on the top and bottom, respectively. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significant.
Welch et al. Arthritis Research & Therapy 2009 11:R14 doi:10.1186/ar2604