Crabp2 expression is increased in joint cartilage from meniscotibial transection (MTX) and partial meniscoectomy (PMX) operated knees. (a) Crabp2 expression was analysed at two, four and six weeks post-surgery and its expression was significantly changed in MTX/PMX-operated knees (n = 5 to 7) in comparison to either the contralateral knee or a sham control. Significance was determined by analysis of variance (ANOVA) with Tukey's post-hoc tests for multiple comparisons. Gene expression was normalised to an 18S internal control and the normalised expression for each gene is shown for the contralateral unoperated right knee, a sham control (left) knee and the operated left knee. Significance to the contralateral and sham controls is indicated on the top and bottom, respectively. (b) The expression of Crabp2 is still elevated 10 weeks post-surgery. Significance in gene expression at 10 weeks post-surgery was determined by two-tailed t-test analysis of the left (L, operated) versus right (R, contralateral control) knee. No sham was included in the 10-week group. * p < 0.05; ** p < 0.01; ns = not significant.
Welch et al. Arthritis Research & Therapy 2009 11:R14 doi:10.1186/ar2604