Hc-gp 39, HexA and HexB gene expression in arthritis patients' synovial membrane and fibroblast samples. Rheumatoid arthritis (RA) and osteoarthritis (OA) synovial fibroblasts (SFs) have significantly higher Hc-gp 39 gene expression as compared with RA and OA synovial membranes (SMs) (Mann – Whitney rank sum test). Hexosaminidase A subunit (HexA) gene expression was approximately the same in SFs and in SM tissue samples. Hexosaminidase B subunit (HexB) gene was characterized by significantly higher gene expression in RA and OA SFs as compared with RA and OA SM tissue samples (Mann – Whitney rank sum test). Gex, gene expression; HGPRT, hypoxanthine phosphoribosyl transferase. *P < 0.05, **P < 0.01, ***P < 0.001.
Pásztói et al. Arthritis Research & Therapy 2009 11:R68 doi:10.1186/ar2697