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Highly Accessed Open Badges Review

Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?

Angelo L Gaffo1, N Lawrence Edwards2 and Kenneth G Saag3*

Author Affiliations

1 Birmingham VA Medical Center. 700 19th St S. Birmingham, AL 35233, USA

2 Division of Rheumatology, University of Florida. Gainesville, FL 32610, USA

3 Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, FOT 820, 1530 3rd Ave South, Birmingham, AL 35294, USA

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Arthritis Research & Therapy 2009, 11:240  doi:10.1186/ar2761

Published: 19 August 2009


An association between high levels of serum urate and cardiovascular disease has been proposed for many decades. However, it was only recently that compelling basic science data, small clinical trials, and epidemiological studies have provided support to the idea of a true causal effect. In this review we present recently published data that study the association between hyperuricemia and selected cardiovascular diseases, with a final conclusion about the possibility of this association being causal.