Email updates

Keep up to date with the latest news and content from Arthritis Research & Therapy and BioMed Central.

Open Badges Editorial

Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems

Guido Valesini* and Cristiano Alessandri

Author Affiliations

Dipartimento di Clinica e Terapia Medica, Reumatologia, Sapienza Università di Roma, V.le del Policlinico 155, 00161 Rome, Italy

For all author emails, please log on.

Arthritis Research & Therapy 2009, 11:125  doi:10.1186/ar2786

See related research by Ursum et al.,

Published: 14 September 2009


In a previous issue of Arthritis Research and Therapy, Ursum and colleagues report the relative stabilities of anticitrullinated protein/peptide antibodies (ACPAs) and IgM rheumatoid factors during the course of rheumatoid arthritis and their differential correlation with markers of the acute-phase response. These findings add to a growing body of evidence highlighting the distinct nature of these two autoantibody systems and the role of ACPAs as a disease-specific marker of rheumatoid arthritis.