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Highly Accessed Open Badges Editorial

Biomarkers: in combination they may do better

Frances MK Williams

Author Affiliations

Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK

Arthritis Research & Therapy 2009, 11:130  doi:10.1186/ar2839

See related research by Dam et al.,

Published: 29 October 2009


The field of biomarkers is a growing one, particularly in osteoarthritis (OA). OA is the most common disabling condition in older persons and a major cause of morbidity. While the debate continues about which of the involved tissues - cartilage, bone or synovium - is the most important in OA aetiology, there is no doubt that the three develop abnormalities in concert; perhaps a truly useful biomarker will reflect just that. While efforts continue to identify reliable biomarkers useful for characterising the status, prognosis and measurement of treatment response in OA, combining existing biomarkers to improve their accuracy looks promising.