Schematic B-cell development of B2 B cells emigrating as immature B cells from the bone marrow and differentiating further into naïve/marginal zone (MZ) B cells in the spleen, which subsequently undergo T cell-dependent differentiation into memory B cells and plasma cells. Secondary lymphoid tissue refers to spleen, tonsil, lymph node, and Peyer's patches. CSR, class-switch recombination; GC, germinal center; MALT, mucosal-associated lymphoid tissue; NF, nuclear factor expression; PC, plasma cells; SC, stem cell; SHM, somatic hypermutation; T1, transitional 1; T2, transitional 2.
Dörner et al. Arthritis Research & Therapy 2009 11:247 doi:10.1186/ar2780