Histological changes in CIA mice after treatment with CD40 siRNA. At the end point of observation, mice were sacrificed. The joints from the mice treated with CD40 siRNA a) and control siRNA b) were collected, fixed, and stained with H&E. The hisopathological change was scored c). Original magnification × 100. Results are representative of seven mice.
Zheng et al. Arthritis Research & Therapy 2010 12:R13 doi:10.1186/ar2914