Influence of norepinephrine (NE) and cortisol (Cort) on human neutrophil peptides 1-3 (HNP1-3) levels in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). (a, b) Influence of norepinephrine on HNP1-3 levels in supernatants of mixed synoviocytes. The data are derived from five OA and five RA patients (two replicates of every patient). Control HNP1-3 values were as described in the legend of Figure 4. (c, d) Influence of cortisol or norepinephrine plus cortisol on HNP1-3 levels in supernatants of mixed synoviocytes. The data are derived from nine OA and seven RA patients (three replicates of every patient). Control HNP1-3 levels were 160.2 ± 50.3 pg/ml in OA patients and 73.5 ± 19.9 pg/ml in RA patients.
Riepl et al. Arthritis Research & Therapy 2010 12:R110 doi:10.1186/ar3044