Effect of NT and CT telopeptides and dynamic compression (15%, 1 Hz) on NO release (a) and sGAG content (b). Unstrained and strained constructs were cultured with 50 μM NT or CT peptide and/or 1 mM 1400 W for 48 hours (n = 8). SN and SC peptides (50 μM) were used as negative controls. NH2-FN-f (1 μM) was used as a positive control. (*) indicates significant comparisons in unstrained constructs for no treatment vs fragment; (ψ) indicates significant comparisons in unstrained constructs for fragment vs fragment + 1400 W; + P < 0.05, ++ P < 0.01, +++ P < 0.001 indicates significant comparisons between treatment conditions as shown (n = 6).
Chowdhury et al. Arthritis Research & Therapy 2010 12:R82 doi:10.1186/ar3009