Expression patterns of genes in RASF during the different cell culture passages. Example for cDNA arrays of the rheumatoid arthritis synovial fibroblasts (RASF) in different passages from one RA patient. Sections of the Atlas Human Cancer cDNA Expression Arrays are shown. (a) Passage 2, (b) passage 4 with mostly constant expression when compared with passage 2, (c) passage 5 with changes about 7% of the expressed genes when compared with passage 2, and (d) passage 8 with changes about 10% of the expressed genes when compared with passage 2. p, passage.
Neumann et al. Arthritis Research & Therapy 2010 12:R83 doi:10.1186/ar3010