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Open Badges Editorial

Exercise-induced changes in interleukin-10 in patients with knee osteoarthritis: new perspectives?

Willem F Lems* and Debby den Uyl

Author Affiliations

VU University Medical Centre, Department of Rheumatology, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

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Arthritis Research & Therapy 2010, 12:131  doi:10.1186/ar3084

See related research by Helmark et al.,

Published: 29 July 2010


Osteoarthritis (OA) of the knee is a common chronic disease leading to increased morbidity and reduced quality of life. Although exercise therapy has been shown to be beneficial for both pain and physical functioning, its underlying mechanism is not fully understood. However, a recent study found an exercise-induced increase in interleukin-10 levels, to which anti-inflammatory and chondroprotective properties are ascribed, in the (peri-)synovial fluid of patients with knee OA. These interesting results provide more insight into the effects of exercise in OA and need to be validated and confirmed. Hopefully, the study offers a promising basis for further research