Additional file 1.
Figure S1. Administration of glucosamine in severe CIOA. ICR mice were injected with high dose of collagenase (two i.a. injections with 2 U/mouse at Day 0 and Day 2). After 7 days glucosamine hydrochloride was administered orally at a dose of 20 mg/kg for 20 days. (a) Representative joint sections stained with H&E showed a mild effect of glucosamine on osteophyte formation and bone remodeling at Day 30 of severe CIOA. (b) Histological score of CIOA joints was not significantly affected by glucosamine. The data are expressed as the mean ± SD from two independent experiments involving five mice per group.
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Ivanovska and Dimitrova Arthritis Research & Therapy 2011 13:R44 doi:10.1186/ar3283