Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes
Department of Medicine/Rheumatology, MetroHealth Medical Centre, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
Arthritis Research & Therapy 2011, 13:R93 doi:10.1186/ar3368
See related editorial by Katiyar and Raman, http://arthritis-research.com/content/13/4/121Published: 17 June 2011
Additional file 1:
Effect of EGCG on nitrite production by human OA chondrocytes stimulated with IL-1β. (a) Chondrocytes were pretreated with EGCG (100 μM) for 2 h then stimulated with IL-1β (5 ng/ml) for 24 h and the culture supernatant was used for providing the cytokine antibody array. Bar represents mean ± SD of three patients, # represents P < 0.05 Vs control; * P < 0.05 Vs IL-1β stimulated chondrocytes. (b-e) Represents cytokine-antibody arrays showing the effects of EGCG on the expression pattern of cytokines produced by human OA chondrocytes upon IL-1β-stimulation. For the array layout and identification of cytokines please see additional file 2.
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Additional file 2:
Comprehensive map of cytokines antibody array.
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