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Open Access Highly Accessed Open Badges Research article

Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes

Nahid Akhtar and Tariq M Haqqi*

Author Affiliations

Department of Medicine/Rheumatology, MetroHealth Medical Centre, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA

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Arthritis Research & Therapy 2011, 13:R93  doi:10.1186/ar3368

See related editorial by Katiyar and Raman,

Published: 17 June 2011

Additional files

Additional file 1:

Effect of EGCG on nitrite production by human OA chondrocytes stimulated with IL-1β. (a) Chondrocytes were pretreated with EGCG (100 μM) for 2 h then stimulated with IL-1β (5 ng/ml) for 24 h and the culture supernatant was used for providing the cytokine antibody array. Bar represents mean ± SD of three patients, # represents P < 0.05 Vs control; * P < 0.05 Vs IL-1β stimulated chondrocytes. (b-e) Represents cytokine-antibody arrays showing the effects of EGCG on the expression pattern of cytokines produced by human OA chondrocytes upon IL-1β-stimulation. For the array layout and identification of cytokines please see additional file 2.

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Additional file 2:

Comprehensive map of cytokines antibody array.

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Additional file 3:

Primer sequences used to quantify gene expression with real-time PCR.

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Open Data