Gene expression and production of TRAF-6 and IRAK-1 in IL-1β-stimulated human OA chondrocytes. (a) and (c) Effect of EGCG pretreatment on the gene expression of TRAF-6 and IRAK-1 in IL-1β-stimulated OA chondrocytes, respectively. (b) and (d) Effect of EGCG on the production of TRAF-6 and IRAK-1 in IL-1β-stimulated OA chondrocytes, respectively. Value represents Mean ± SD of three different patients. # represents P < 0.05 Vs control; * P < 0.05 Vs IL-1β stimulated chondrocytes. EGCG, epigallocatechin-3-gallate; IL, interleukin; IRAK-1, interleukin-1 receptor-associated kinase 1; TRAF-6, TNF receptor-associated factor 6.
Akhtar and Haqqi Arthritis Research & Therapy 2011 13:R93 doi:10.1186/ar3368