Open Access Open Badges Research article

Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients

María Teruel1*, Jose-Ezequiel Martin1, Carlos González-Juanatey2, Raquel López-Mejias3, Jose A Miranda-Filloy4, Ricardo Blanco3, Alejandro Balsa5, Dora Pascual-Salcedo5, Luis Rodriguez-Rodriguez6, Benjamin Fernández-Gutierrez6, Ana M Ortiz7, Isidoro González-Alvaro7, Carmen Gómez-Vaquero8, Nunzio Bottini9, Javier Llorca10, Miguel A González-Gay3 and Javier Martin1

Author affiliations

1 Instituto de Parasitología y Biomedicina "López-Neyra", IPBLN-CSIC, Avd. del Conocimiento s/n. 18010. Granada, Spain

2 Division of Cardiology, Hospital Xeral-Calde, Dr Ochoa s/n, 27004, Lugo, Spain

3 Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Avenida de Valdecilla s/n, 39008, Santander, Spain

4 Rheumatology Division, Hospital Xeral-Calde, Dr Ochoa s/n, 27004, Lugo, Spain

5 Rheumatology Service, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain

6 Servicio de Reumatología, Hospital Clinico San Carlos, C/Profesor Martín Lagos, S/N, 28040 Madrid, Spain

7 Rheumatology Service, Hospital Universitario La Princesa, C/Diego de León, 62,28006, Madrid, Spain

8 Rheumatology Service, Hospital Universitari Bellvitge, Feixa Llarga s/n, 08907, Hospitalet de Llobregat, Barcelona, Spain

9 Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA

10 Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IFIMAV, Avenida del Cardenal Herrera Oria, 39011, Santander, Spain

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Citation and License

Arthritis Research & Therapy 2011, 13:R116  doi:10.1186/ar3401

Published: 18 July 2011



Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACP1 polymorphisms to susceptibility to rheumatoid arthritis (RA), as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease (CV) observed in RA patients.


A set of 1,603 Spanish RA patients and 1,877 healthy controls were included in the study. Information related to the presence/absence of CV events was obtained from 1,284 of these participants. All individuals were genotyped for four ACP1 single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247, and rs3828329, using a predesigned TaqMan SNP genotyping assay. Classical ACP1 alleles (*A, *B and *C) were imputed with SNP data.


No association between ACP1 gene polymorphisms and susceptibility to RA was observed. However, when RA patients were stratified according to the presence or absence of CV events, an association between rs11553742*T and CV events was found (P = 0.012, odds ratio (OR) = 2.62 (1.24 to 5.53)). Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA (P = 0.024, OR = 2.43).


Our data show that the ACP1*C allele influences the risk of CV events in patients with RA.