Synovial fluid hydroxyeicosatetraenoic acid (HETE) (a-d) and leukotriene B4 (LTB4) (e) concentrations during lipopolysaccharide (LPS)-induced synovitis. Horses were treated with a non-steroidal anti-inflammatory drug (NSAID) (meloxicam, 0.6 mg/kg once a day by mouth; n = 6) or placebo (n = 6) starting at 2 hours after LPS injection for a total of seven treatments. Individual HETEs respond differentially to LPS and NSAID treatment. Boxes depict median and interquartile range; whiskers denote minimum and maximum values. *P < 0.05.
de Grauw et al. Arthritis Research & Therapy 2011 13:R123 doi:10.1186/ar3427