Affected and contralateral percentage stance time in rats with lumbar radiculopathy (five days post-operation). A significant correlation between percentage stance time and velocity is observed in walking rats (upper left and right); raw data with a linear fit of the pre-operative data are shown. As velocity increases, percentage stance time decreases in both the affected (right) and contralateral (left) limb. After accounting for this correlation, decreased affected limb percentage stance times (bottom right), but not contralateral limb stance times (bottom left) can be identified in animals with NP alone relative to pre-operative and sham controls (P = 0.010, P = 0.013, respectively). While sTNFRII treatment improved stance time imbalance resulting from NP application to the L5 DRG (see Figure 1), improvement in the stance time balance in the sTNFRII treated rats appears to result from a relative decrease in both the affected and contralateral limb stance times relative to pre-operative and sham controls.
Allen et al. Arthritis Research & Therapy 2011 13:R137 doi:10.1186/ar3451