Mechanical sensitivity in the affected and contralateral limb of rats with lumbar radiculopathy (five days post-operation). Rats with NP alone had significant decreases in the mechanical withdrawal threshold of their affected limb relative to their contralateral limb (∀, P = 0.032) and pre-operative controls (*, P = 0.001). Sham controls also had significant decreases in their mechanical withdrawal threshold relative to pre-operative controls (* P = 0.030). Rats receiving NP and sTNFRII treatment had improved mechanical withdrawal thresholds relative to rats with NP alone (^, P = 0.013). Data presented as mean + standard error.
Allen et al. Arthritis Research & Therapy 2011 13:R137 doi:10.1186/ar3451