Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis
1 Laboratory of Autoimmunity, The Medical College of Xiamen University, Xiamen University, 361005, China
2 Section of Immunoregulation, Research center Borstel, Borstel, 23845, Germany
3 Department of Dermatology, University of Lübeck, Lübeck, 23538, Germany
Arthritis Research & Therapy 2011, 13:132 doi:10.1186/ar3490
See related research by Yu et al., http://arthritis-research.com/content/13/5/R143Published: 31 October 2011
Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.