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Highly Accessed Open Badges Editorial

Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Xinhua Yu12 and Saleh M Ibrahim3*

Author Affiliations

1 Laboratory of Autoimmunity, The Medical College of Xiamen University, Xiamen University, 361005, China

2 Section of Immunoregulation, Research center Borstel, Borstel, 23845, Germany

3 Department of Dermatology, University of Lübeck, Lübeck, 23538, Germany

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Arthritis Research & Therapy 2011, 13:132  doi:10.1186/ar3490

See related research by Yu et al.,

Published: 31 October 2011


Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.