Comparison of the gene expression patterns of mycobacterial heat shock protein 65-tolerized rats and rats with preclinical adjuvant arthritis. (A) DEGs in LNCs of mycobacterial heat shock protein 65 (Bhsp65)-tolerized rats (T) and rats with preclinical AA (P) are shown. Also shown are DEGs shared (S) between the two groups (data derived from Figure 4). (B) Bland-Altman plots. The x-axis represents the average fold change of each sample measured by quantitative real-time PCR (qPCR) and microarrays. The y-axis is the difference in fold change calculated by qPCR measurement minus microarray measurements for each sample. The solid line (y = 14.89) is the mean difference in fold change of all the samples. The two dotted lines represent two standard deviations from the mean. AA: adjuvant arthritis; DEG: differentially expressed gene; LNC: lymph node cell; med: medium.
Yu et al. Arthritis Research & Therapy 2011 13:R143 doi:10.1186/ar3457