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Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis

Seung-Jun Hwang1, Bongkun Choi2, Soon-Suk Kang2, Jae-Ho Chang3, Yong-Gil Kim4, Yeon-Ho Chung2, Dong Hyun Sohn5, Min Wook So4, Chang-Keun Lee4, William H Robinson5 and Eun-Ju Chang12*

Author Affiliations

1 Department of Anatomy and Cell Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea

2 Department of Medicine, Graduate School, Cellular Dysfunction Research Center and BMIT, University of Ulsan College of Medicine, Seoul 138-736, Korea

3 Department of Natural Science, College of Natural Science, Sang-Ji University, Wonju 220-702, Korea

4 Department of Internal Medicine, Division of Rheumatology, University of Ulsan College of Medicine, Seoul 138-736, Korea

5 Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford CA 94305, USA

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Arthritis Research & Therapy 2012, 14:R14  doi:10.1186/ar3693

Published: 20 January 2012

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Additional file 1:

Characteristics of patients with rheumatoid arthritis (RA). All patients were 30 years or older at the time of RA diagnosis and their mean ± SD age was 53.3 ± 16.0 years. All patients were positive for rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody and had a diagnosis of RA with a median baseline Disease Activity Score 28 (DAS28) of 5.27 (range 2.9 to 7.4), a median 1 year DAS28 of 2.58 (1.7 to 3.4), a baseline median erythrocyte sedimentation rate of 69.6 (28 to 120), and a median baseline C-reactive protein (CRP) of 1.05 (0.1 to 2.04). With regard to medications used for the treatment of RA, patients were treated with prednisolone and disease-modifying antirheumatic drugs (DMARDs) including methotrexate, sulfasalazine, leflunomide, FK506, and/or hydroxychloroquine. SD, standard deviation.

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