Levels of inflammatory cytokines are higher in OA compared with healthy sera. Cytokines whose levels differ significantly between sera from individuals with osteoarthritis (OA) and sera from age-matched healthy individuals (FDR < 10%). Significance analysis of microarrays (SAM) was used to identify statistically significant differences, and the SAM-generated results were subjected to unsupervised hierarchic clustering. Cytokine levels were measured with a multiplex bead-based immunoassay. Samples from individual patients are listed above the heatmap, and the individual cytokines are listed to the right of the heatmap. IL, interleukin; MIG, monokine induced by IFN-γ; IP-10, interferon gamma-induced protein 10; IL-1ra, interleukin-1 receptor antagonist; VEGF, vascular endothelial growth factor; GM-CSF, granulocyte macrophage colony-stimulating factor; MCP, monocyte chemotactic protein; HGF, hepatocyte growth factor; GROα, growth-regulated oncogene α; MIP-1β, macrophage inflammatory protein 1β; M-CSF, macrophage colony-stimulating factor; SCGF-β, stem cell growth factor β; G-CSF, granulocyte colony-stimulating factor; CTACK, cutaneous T-cell attracting chemokine.
Sohn et al. Arthritis Research & Therapy 2012 14:R7 doi:10.1186/ar3555