The effect of TFM-C on CAIA. A. Clinical scores of CAIA in B6 mice treated with 10 μg/g TFM-C (closed circles), celecoxib (open triangles) or vehicle (open squares) every other day from two days before CAIA induction. * P < 0.05 compared with control group, * P < 0.05 compared with both control and celecoxib-treated groups. Results shown are the mean + SEM of five mice per group. The data shown are from a single experiment representative of two similar experiments. B. Quantification of histological assessment of joints 12 days after induction of AIA shown in A. Results shown are the mean + SEM of five mice per group. * P < 0.05 control versus TFM-C group, * P < 0.05 celecoxib versus TFM-C -treated group. C. Representative histological feature of joints in vehicle-treated (left), TFM-C-treated (middle) and celecoxib-treated (right) mice. (H&E stained; original magnification × 40).
Chiba et al. Arthritis Research & Therapy 2012 14:R9 doi:10.1186/ar3683