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Correction: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development

Rizwanul Haque1, Fengyang Lei1, Xiaofang Xiong1, Yuzhang Wu2 and Jianxun Song12*

Author affiliations

1 Department of Microbiology & Immunology and Penn State Hershey Cancer Institute, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA

2 Institute of Immunology, The Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, PR China

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Citation and License

Arthritis Research & Therapy 2012, 14:401  doi:10.1186/ar3790

See related research by Haque et al.,

The electronic version of this article is the complete one and can be found online at:

Published:10 April 2012

© 2012 BioMed Central Ltd


Following publication of our recent article [1], it was brought to our attention that there are errors in Figure 5b and Supplementary Table 2.

The corrected Figure and table are given here as Figure 1 (a corrected version of Figure 5b [1]) and Table 1 (a corrected version of Supplementary Table 2 [1]).

thumbnailFigure 1. Adoptive cell transfer of FoxP3- and Bcl-xL-transduced regulatory T cells suppresses collagen-induced arthritis (CIA).

Table 1. Summary of the mouse arthritis scores of the three experiments

Naive CD4+ T cells from DBA/1J mice were stimulated with anti-CD3 plus anti-CD28 antibodies. On days 2 and 3, the cells were transduced with retroviral constructs: vector (Mig), FoxP3 (Mig-FoxP3), or FoxP3 with Bcl-xL (Mig-Bcl-xL-2A-FoxP3). On day 6, green fl uorescent protein-positive (GFP+) T cells were sorted and prepared for adoptive cell transfer. CIA was induced in male DBA/1J mice (>4 months old) by one (day 0) intradermal immunization in the base of the tail with 100 μg of bovine type II collagen in complete Freund's adjuvant, containing 5 mg/mL killed Mycobacterium tuberculosis (H37Ra). On day 15 after the immunization, the mice received transduced GFP+ cells (2.5 × 106 per mouse, six mice per group). In the following days, the arthritis clinical score was evaluated by examining the paws and using a 4-point scale: 0, normal paw; 1, minimal swelling or redness; 2, redness and swelling involving the entire forepaw; 3, redness and swelling involving the entire limp; 4, joint deformity or ankylosis or both. Values are the mean ± standard error of the mean of data obtained in three experiments, and in each experiment, six mice per group were used.


  1. Haque R, Lei F, Xiong X, Wu Y, Song J: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development.

    Arthritis Res Ther 2010, 12:R66. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL