Scheme of collagen-induced arthritis induction and statin administration. Mice were immunized at day 0 (IMM) and challenged at day 21 (CHA), after which arthritis was scored three times a week until day 42. Atorvastatin (A) or pravastatin (P) were given daily, either before (day -28 until day 20) or after (day 22 until day 42) collagen-induced arthritis (CIA) induction. Mice were euthanized at day 42.
Vandebriel et al. Arthritis Research & Therapy 2012 14:R90 doi:10.1186/ar3814