Effect of statin treatment on arthritis incidence and score. (A) Number of arthritic animals per group versus time after immunization. (B) Summed arthritis score per group of animals versus time after immunization. Mice were immunized at day 0 and challenged at day 21, after which arthritis was scored three times a week until day 42. Statins were given daily. Black circles connected by dotted line, atorvastatin before collagen-induced arthritis (CIA) induction; black squares connected by dotted line, atorvastatin after CIA induction; black triangles connected by dotted line, pravastatin before CIA induction; black inverted triangles connected by dotted line, pravastatin after CIA induction; black diamonds connected by continuous line, CIA control. n = 12 per group.
Vandebriel et al. Arthritis Research & Therapy 2012 14:R90 doi:10.1186/ar3814