Anti-collagen type II IgG levels. Mice were immunized at day 0 and challenged at day 21. Atorvastatin (A) or pravastatin (P) were given daily, either before (day -28 until day 20) or after (day 22 until day 42) collagen-induced arthritis induction. Mice were euthanized at day 42. Control mice (C) did not receive statins. Anti-collagen type II (anti-CII) IgG was measured in serum by ELISA. *Significantly different (P < 0.05) from C. n = 12 per group. One-way analysis of variance, followed by the Bonferroni post hoc test.
Vandebriel et al. Arthritis Research & Therapy 2012 14:R90 doi:10.1186/ar3814