Approaching the immunophysiology of steroid resistance
Section of Rheumatology, Department of Medicine, Yale University School of Medicine, TAC S525, PO Box 208031, 300 Cedar Street, New Haven, CT 06520-8031, USA
Arthritis Research & Therapy 2012, 14:118 doi:10.1186/ar3820
See related research by Wang et al., http://arthritis-research.com/content/14/3/R103Published: 18 May 2012
Wang and colleagues have investigated a mechanistic basis for resistance to steroid therapy in systemic lupus erythematosus patients. Their examination reveals significant differences in macrophage migration inhibitory factor (MIF)-dependent expression of IκB, which is a critical cellular regulator of the broadly proinflammatory transcription factor NF-κB. Their studies also suggest that MIF may be a clinically useful biomarker in systemic lupus erythematosus and support the therapeutic targeting of MIF as a means to reduce clinical steroid resistance.