Distribution of anti-native human collagen type II (anti-CII) antibodies. A) the distribution of anti-CII antibodies among 100 healthy blood donors is shown; B) the distribution of anti-CII antibodies among 274 patients with RA ; radiological data were available for 256 of these patients. The vertical arrow represents the cutoff value separating the majority of patients with rheumatoid arthritis (RA) and the discrete group with very high anti-CII levels associated with cytokine production in our in vitro immune complex assay [7,8].
Mullazehi et al. Arthritis Research & Therapy 2012 14:R100 doi:10.1186/ar3825