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Elevated levels of fibrinogen-derived endogenous citrullinated peptides in synovial fluid of rheumatoid arthritis patients

Reinout Raijmakers1*, Joyce JBC van Beers2, Mahmoud El-Azzouny1, Natasja FC Visser1, Borut Božič3, Ger JM Pruijn2 and Albert JR Heck1*

Author Affiliations

1 Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Centre, Padualaan 8, Utrecht, 3584 CH, The Netherlands

2 Department of Biomolecular Chemistry, Nijmegen Center for Molecular Life Sciences, Institute for Molecules and Materials, Radboud University Nijmegen, Geert Grooteplein 26, Nijmegen, 6525 GA, The Netherlands

3 University Medical Centre Ljubljana, Department of Rheumatology, Immunology Laboratory, Vodnikova 62, Ljubljana, 1000, Slovenia

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Arthritis Research & Therapy 2012, 14:R114  doi:10.1186/ar3840

Published: 14 May 2012

Additional files

Additional file 1:

A PDF file containing all supplementary methods, tables and figures as referred to in the main text. The additional file contains supplementary methods on 'LC-MS/MS' and 'Identification and quantitation of endogenous peptides', a link to all identification results as deposited in the Tranche, supplementary tables S1 ('List of patients included and CCP status of RA patients') and S2 ('LC-MS characteristics of identified citrullinated peptides and their noncitrullinated counterparts') and supplementary figures S1 ('Abundance of fibrinogen amino acids 414-433-derived peptides in RA patients and controls'), S2 ('Relative abundance of citrullinated peptides and their noncitrullinated counterparts') and S3 ('The presence of phosphorylated and citrullinated peptides in synovial fluid').

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