Platelet-derived growth factor receptor expression and collagen deposition. Rituximab (RTX)-induced resolution of skin fibrosis associates with attenuation of platelet-derived growth factor receptor (PDGFR) expression. RTX treatment mediates a significant decrease of (B) PDGFRα and (C) PDGFRβ expression on spindle-like cells in the papillary dermis, which associates with attenuation of collagen deposition (A). No change in both PDGFR expression and collagen deposition was found in Patients 4 and 6, indicating a strong link between PDGFR expression and fibrosis.
Daoussis et al. Arthritis Research & Therapy 2012 14:R145 doi:10.1186/ar3879